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Abstract We measure the CO-to-H₂conversion factor (α_CO) in 37 galaxies at 2 kpc resolution, using the dust surface density inferred from far-infrared emission as a tracer of the gas surface density and assuming a constant dust-to-metal ratio. In total, we have ∼790 and ∼610 independent measurements ofα_COfor CO (2–1) and (1–0), respectively. The mean values forα_{CO (2–1)}andα_{CO (1–0)}are ${9.3}_{-5.4}^{+4.6}$and ${4.2}_{-2.0}^{+1.9}{M}_{\odot }{\mathrm{pc}}^{-2}{\left(\mathrm{K}\mathrm{km}{\mathrm{s}}^{-1}\right)}^{-1}$, respectively. The CO-intensity-weighted mean is 5.69 forα_{CO (2–1)}and 3.33 forα_{CO (1–0)}. We examine howα_COscales with several physical quantities, e.g., the star formation rate (SFR), stellar mass, and dust-mass-weighted average interstellar radiation field strength ( $\overline{U}$). Among them, $\overline{U}$, Σ_SFR, and the integrated CO intensity (W_CO) have the strongest anticorrelation with spatially resolvedα_CO. We provide linear regression results toα_COfor all quantities tested. At galaxy-integrated scales, we observe significant correlations betweenα_COandW_CO, metallicity, $\overline{U}$, and Σ_SFR. We also find thatα_COin each galaxy decreases with the stellar mass surface density (Σ_⋆) in high-surface-density regions (Σ_⋆≥ 100M_⊙pc⁻²), following the power-law relations ${\alpha }_{\mathrm{CO}(2–1)}\propto {\mathrm{\Sigma }}_{\star }^{-0.5}$and ${\alpha }_{\mathrm{CO}(1–0)}\propto {\mathrm{\Sigma }}_{\star }^{-0.2}$. The power-law index is insensitive to the assumed dust-to-metal ratio. We interpret the decrease inα_COwith increasing Σ_⋆as a result of higher velocity dispersion compared to isolated, self-gravitating clouds due to the additional gravitational force from stellar sources, which leads to the reduction inα_CO. The decrease inα_COat high Σ_⋆is important for accurately assessing molecular gas content and star formation efficiency in the centers of galaxies, which bridge “Milky Way–like” to “starburst-like” conversion factors. 

Abstract We present a rich, multiwavelength, multiscale database built around the PHANGS–ALMA CO (2 − 1) survey and ancillary data. We use this database to present the distributions of molecular cloud populations and subgalactic environments in 80 PHANGS galaxies, to characterize the relationship between population-averaged cloud properties and host galaxy properties, and to assess key timescales relevant to molecular cloud evolution and star formation. We show that PHANGS probes a wide range of kpc-scale gas, stellar, and star formation rate (SFR) surface densities, as well as orbital velocities and shear. The population-averaged cloud properties in each aperture correlate strongly with both local environmental properties and host galaxy global properties. Leveraging a variable selection analysis, we find that the kpc-scale surface densities of molecular gas and SFR tend to possess the most predictive power for the population-averaged cloud properties. Once their variations are controlled for, galaxy global properties contain little additional information, which implies that the apparent galaxy-to-galaxy variations in cloud populations are likely mediated by kpc-scale environmental conditions. We further estimate a suite of important timescales from our multiwavelength measurements. The cloud-scale freefall time and turbulence crossing time are ∼5–20 Myr, comparable to previous cloud lifetime estimates. The timescales for orbital motion, shearing, and cloud–cloud collisions are longer, ∼100 Myr. The molecular gas depletion time is 1–3 Gyr and shows weak to no correlations with the other timescales in our data. We publish our measurements online, and expect them to have broad utility to future studies of molecular clouds and star formation.